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Document Type |
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Article In Journal |
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Document Title |
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Assessment of the impact of Methyl tertiary butyl ether (MTBE) contaminated drinking water on blood hematology Assessment of the impact of Methyl tertiary butyl ether (MTBE) contaminated drinking water on blood hematology |
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Subject |
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Assessment of the impact of Methyl tertiary butyl ether (MTBE) contaminated drinking water on blood hematology |
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Document Language |
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English |
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Abstract |
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Lead was removed from car-fuel and replaced by methyl tertiary butyl ether (MTBE) in the United States since 1979, and other Arab countries in January 2001. MTBE is added to gasoline at 12-15%. It dissolves readily in water and evaporates quickly. This study focused on the possible health hazards of MTBE in drinking water as manifested by changes on blood hematology. The study tries also to draw a quantitative relationship between MTBE concentration and changes of blood hematology. One hundred and twenty male Wistar rats were exposed to five different MTBE concentrations (0.0, 1,000, 1,500, 2,000, 2,500 ppm) for 60 days. The results showed that a significant decrease in white blood cell at 1,000, and 1,500 ppm MTBE by 55.8% and 39.1 % respectively. On the other hand, at 2,000, and 2,500 ppm MTBE, WBC counts increased by 23.3% and 18.4 % respectively. Neutrophils increased significantly at 2,000, and 2,500 ppm MTBE by 61.2, and 53.1 % respectively. Lymphocytes decreased significantly only at 1,000 ppm MTBE by 36.2 %, and increased at 2,000, and 2,500 ppm MTBE by 25.0% and 24.4 % respectively. Mean corpuscular hemoglobin decreased significantly at low MTBE concentrations (1,000, and 1,500 ppm) by 8.6% and 6.2 % respectively, and increased significantly at high MTBE concentrations (2,000, and 2,500 ppm) by 7.4% and 5.2 % respectively. Mean corpuscular hemoglobin concentration decreased significantly at 1,000, and 1,500 ppm MTBE by 9.2% and 7.4 % respectively, and increased significantly at 2,000, and 2,500 ppm MTBE by 8.3% and 5.7% respectively. There was no significant difference at any MTBE concentrations in red blood cell, platelet, hemoglobin, monocytes, eosinophils, basophils, hematocrit, red distribution width, and mean corpuscular volume in treated animals. As a conclusion, MTBE causes inflammation because it alters neutrophils and lymphocytes counts. On the other hand, MTBE did not affect hematologic parameters related to anemia indicating a non-anemic condition. |
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ISSN |
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0 |
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Journal Name |
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Bulletin of Pure and Applied Science |
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Volume |
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25 |
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Issue Number |
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2 |
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Publishing Year |
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1427 AH
2006 AD |
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Number Of Pages |
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11 |
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Article Type |
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Article |
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Added Date |
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Thursday, July 2, 2009 |
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