Main Page
About Science
Faculty Deanship
Letter of Dean
Overview of Deanship
Vice Deans
Vice Dean
Letter of Vice-dean
Overview of Vice-deanship
Vice Dean for Graduate Studies
Letter of Vice Dean for Graduate Studies
Overview of Vice Dean of Postgraduate Studies
Research and Innovation Unit
Vice Dean for Girls Campus
Faculty Management
Letter of Managing Director-Boys Campus
Letter of Managing Director-Girls Campus
Overview of Management
Educational Affairs
Males Campus
Staff
Females Campus
Contact Us
Research
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Faculty of Sciences
Document Details
Document Type
:
Article In Journal
Document Title
:
Genotoxic effect of an organophosphorus pesticide "Ethephon" on somatic and germ cells of male mice
تأثير السمية الوراثية للمبيد الفسفوري إيثوفان على الخلايا الجنسية والجسدية في ذكور الفئران
Subject
:
Biological
Document Language
:
English
Abstract
:
Ethephon [(2-chloroethyl) phosphoric acid] is an organophosphorus pesticide "herbicide". Ethephon was tested for its genotoxic effect in both somatic (bone marrow) and germ (spermatocytes) cells of male mice. Three different dose levels (192, 240 & 480 mg/kg body weight representing 1/10, 1/8, 1/4 from the LD50) were orally administrated in male mice weighted 20-25 gm. An increase in chromosomal aberrations (structural & numerical) was observed in most treatment with ethephon in both somatic and gametic cells. In bone marrow cells, the significant structural chromosome aberrations were in the form of chromatid gaps & breaks, deletions, fragments and centric fusion, while in spermatocytes were in the form of chain, autosome univalent and x-y univalent. On the other hand, the numerical aberrations, such as aneuploidy (hypoploidy 2n- and hyperploidy 2n+), were below the significant level. Concerning the sperm shape abnormalities, there was no significant increase over the control groups. These observed results were attributed to the alkylating potency of the organophosphorus pesticide "herbicide" and also to its cytotoxic effects. From this study, it is possible to conclude that ethephon has clastogenic effects. The very scarce available information on mutagenicity of ethephon, in spite of its widespread use, emphasizes the need for further mutagenicity and carcinogenicity testing of this pesticide.
ISSN
:
0973-1245
Journal Name
:
Biosciences Biotechnology Research Asia, Volume 5, Issue 1, June 2008, Pages 1-8
Volume
:
5
Issue Number
:
1
Publishing Year
:
2008 AH
2008 AD
Number Of Pages
:
8
Article Type
:
Article
Added Date
:
Thursday, October 15, 2009
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ندى حسن على التواتي القرشي
Nada hassan altwaty alqourashy
Researcher
Doctorate
ntwaty@yahoo.com
صالحه يحيى محمد العقيلي
Saleha Yehya Mohammed Alakilli
Researcher
Doctorate
salakilli@kau.edu.sa
Back To Researches Page