Document Details
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Document Type |
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Thesis |
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Document Title |
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EFFECTS OF SOME PLANT OILS ON PHYSIOLOGICAL RESPONSES IN STREPTOZOTOCIN-INDUCED DIABETIC RATS تأثيرات بعض الزيوت النباتية على الاستجابات الفسيولوجية في الجرذان المصابة بداء السكري المستحث بالاستريبتوزوتوسين |
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Subject |
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Biological |
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Document Language |
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Arabic |
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Abstract |
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The present study was aimed to compare the efficacy of neem, sesame, sunflower, evening primrose, neem plus sesame, neem plus evening primrose , neem plus sunflower, sesame plus evening primrose, sesame plus sunflower and evening primrose plus sunflower oils supplementation in streptozotocin (STZ)-diabetic and non-diabetic male Wistar rats. In comparison with control, highly significant increases in the values of blood glucose (318.7%), triglycerides (62.3%), cholesterol (99.2%), low density lipoprotein LDL-cholesterol (170%), total protein (25.5 ), creatinine (82.3%), urea (142.8%), uric acid (191.1%), alanine aminotransferase (118.9%) and aspartate aminotransferase (35.3%) were observed in STZ-diabetic rats, while the value of high density lipoprotein HDL-cholesterol was markedly decline (66.3%). The effects of neem, sesame, sunflower, evening primrose, neem plus sesame, neem plus evening primrose , neem plus sunflower, sesame plus evening primrose, sesame plus sunflower and evening primrose plus sunflower oils on some physiological parameters were examined in streptozotocin (STZ)-induced diabetic and non-diabetic male Wistar rats. STZ-induced diabetic rats given the control diet had the lowest body weight change, thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4) levels after 7 weeks. Diabetic rats given diets containing the oils of neem, sesame, sunflower, evening primrose, neem plus sesame, neem plus evening primrose , neem plus sunflower, sesame plus evening primrose, sesame plus sunflower and evening primrose plus sunflower had higher body weight change, TSH, T3 and T4 levels than diabetic rats given the control diet. No significant differences were observed in the above physiological parameters of normal rats fed on the examined oils when compared with those rats fed on the control diet after 7 weeks. There were no significant differences in body weight change of diabetic rats fed on the diets containing the different oils when compared with normal rats fed on the same diets after 7 weeks. These data indicate that the diets containing the oils of neem, sesame, sunflower, evening primrose, neem plus sesame, neem plus evening primrose , neem plus sunflower, sesame plus evening primrose, sesame plus sunflower and evening primrose plus sunflower improve the examined physiological parameters in STZ-induced diabetic rats. From the present new findings, it was suggested that neem, sesame, sunflower, evening primrose, neem plus sesame, neem plus evening primrose , neem plus sunflower, sesame plus evening primrose, sesame plus sunflower and evening primrose plus sunflower oils supplementation may act as antioxidant agents and these oils could be an excellent adjuvant support in the therapy of diabetic mellitus and its complications. |
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Supervisor |
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Prof.Talal A. Zari |
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Thesis Type |
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Doctorate Thesis |
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Publishing Year |
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1430 AH
2009 AD |
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Added Date |
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Saturday, December 4, 2010 |
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Researchers
| بندر حمد العوفي | AL-OFI, BANDAR HAMAD | Researcher | | |
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