Main Page
About Science
Faculty Deanship
Letter of Dean
Overview of Deanship
Vice Deans
Vice Dean
Letter of Vice-dean
Overview of Vice-deanship
Vice Dean for Graduate Studies
Letter of Vice Dean for Graduate Studies
Overview of Vice Dean of Postgraduate Studies
Research and Innovation Unit
Vice Dean for Girls Campus
Faculty Management
Letter of Managing Director-Boys Campus
Letter of Managing Director-Girls Campus
Overview of Management
Educational Affairs
Males Campus
Staff
Females Campus
Contact Us
Research
عربي
English
About
Admission
Academic
Research and Innovations
University Life
E-Services
Search
Faculty of Sciences
Document Details
Document Type
:
Article In Journal
Document Title
:
Thermal stability of thiazide and related diuretics during superheated water chromatography
Thermal stability of thiazide and related diuretics during superheated water chromatography
Subject
:
Chemistry
Document Language
:
English
Abstract
:
The separations of eleven thiazide and related sulfonamide diuretics using superheated water chromatography at up to 200 °C on an XBridge C18 column were compared with conventional liquid chromatography at ambient temperature. Most of the sulfonamide diuretics were thermally stable, but many of the thiazides were degraded. The most sensitive were the dihydrothiazides, including cyclopenthiazide and hydrochlorothiazide, which were converted to the corresponding aminobenzenedisulfonamides in the pre-column heater. The N-methyl thiazides, including methyclothiazide, appeared to be more stable but degraded on the column and of the thiazides, chlorothiazide eluted largely unchanged although some on-column degradation was observed for benzthiazide. The results confirmed that in superheated water chromatography problems may be encountered with analytes with low storage stability at ambient temperature.
ISSN
:
0009-5893
Journal Name
:
Chromatographia
Volume
:
72
Issue Number
:
11
Publishing Year
:
1431 AH
2010 AD
Article Type
:
Article
Added Date
:
Saturday, October 29, 2011
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
G Huang
Huang, G
Researcher
Doctorate
R M Smith
Smith, R M
Researcher
Doctorate
r.m.smith@lboro.ac.uk
حسن مبروك البشري
Albishri, Hassan M
Researcher
Doctorate
hmalbeshri@kau.edu.sa
JinMing Lin
Lin, JinMing
Researcher
Doctorate
Files
File Name
Type
Description
31179.pdf
pdf
Abstract
Back To Researches Page