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Document Details
Document Type
:
Article In Journal
Document Title
:
Acylated pregnane glycosides from Caralluma quadrangula
Acylated pregnane glycosides from Caralluma quadrangula
Document Language
:
English
Abstract
:
In a previous study, the methanolic extract as well as the chloroform fraction of the aerial parts of Caralluma quadrangula (Forssk.) N.E.Br. indigenous to Saudi Arabia showed significant in vitro cytotoxic activity against breast cancer (MCF7) cell line. In a biologically-guided fractionation approach, four acylated pregnane glycosides were isolated from the chloroform fraction of C. quadrangula. The structures of the isolated compounds were elucidated by the analysis of their MS and NMR data. The compounds were identified as 12,20-di-O-benzoylboucerin 3-O-beta-D-digitoxopyranosyl-(1 -> 4)-beta-D-canaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (1), 12,20-di-O-benzoylboucerin 3-O-beta-D-cymaropyranosyl-(1 -> 4)-beta-D-canaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (2), 12,20-di-O-benzoylboucerin 3-O-beta-D-glucopyranosyl-(1 -> 4)-beta-D-digitoxopyranosyl-(1 -> 4)-beta-D-canaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (3) and 12,20-di-O-benzoyl-3 beta,5 alpha,12 beta,14 beta,20-pentahydroxy-(20R)-pregn-6-ene 3-0-beta-D-glucopyranosyl-(1 -> 4)-beta-D-digitoxopyranosyl-(1 -> 4)-beta-D-canaropyranosyl-(1 -> 4)-beta-D-cymaropyranoside (4). The isolated compounds were tested for their cytotoxic activity against breast cancer (MCF7) cell line
ISSN
:
0031-9422
Journal Name
:
PHYTOCHEMISTRY
Volume
:
88
Issue Number
:
1
Publishing Year
:
1434 AH
2013 AD
Article Type
:
Article
Added Date
:
Wednesday, July 26, 2017
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
Hossam Abdallah
Abdallah, Hossam
Researcher
Abdel-Moneim Osman
Osman, Abdel-Moneim
Researcher
Hussein Almehdar
Almehdar, Hussein
Researcher
Essam Abdel-Sattar
Abdel-Sattar, Essam
Researcher
Files
File Name
Type
Description
42275.pdf
pdf
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